I wouldn't clean it up manually. Some of the files may still be needed by something. It looks like you're using Fedora or something RHEL-based, both of which have a cleanup jump for /tmp (and /var/tmp if I remember correctly). As long as you have cron running you shouldn't have to worry about those directories, unless you're really really hurting for disk space :-)
Sean
Seem to have a lot of old stuff (old file date garbage?) in /usr/tmp.
Is there any reason I should not delete any of this old stuff?
-rw------- 1 root 48 Jul 26 2011
dkms_rpm_safe_upgrade_lock.11831.TBQyoK
-rw------- 1 root 56 Jul 26 2011
dkms_rpm_safe_upgrade_lock.11831.GIqT1u
-rw------- 1 root 61 Jul 26 2011
dkms_rpm_safe_upgrade_lock.11831.ZdFFpR
-rw------- 1 root 48 Aug 4 2011
dkms_rpm_safe_upgrade_lock.31420.iZaAkD
-rw------- 1 root 58 Aug 4 2011
dkms_rpm_safe_upgrade_lock.31420.uAXaLC
-rw------- 1 root 155 Aug 4 2011 init.5UFrQu
-rw-r--r-- 1 root 766966 Aug 4 2011 index.html
-rw-r--r-- 1 root 216 Aug 4 2011 lomanager-install.log
-rw------- 1 root 56 Aug 10 2011
dkms_rpm_safe_upgrade_lock.11278.MvLRdl
-rw------- 1 root 87 Aug 17 2011 init.CkseTK
-rw------- 1 root 58 Sep 7 2011
dkms_rpm_safe_upgrade_lock.7730.HPMuoC
-rw------- 1 root 48 Sep 7 2011
dkms_rpm_safe_upgrade_lock.7730.g2msVI
-rw------- 1 root 0 Nov 6 2011 init.EjTmLP
-rw------- 1 root 0 Nov 6 2011 init.SbAMmV
-rw------- 1 root 48 Dec 3 2011
dkms_rpm_safe_upgrade_lock.13009.odxfw4
-rw------- 1 root 58 Dec 3 2011
dkms_rpm_safe_upgrade_lock.13009.lVSXdy
-rw------- 1 root 56 Dec 3 2011
dkms_rpm_safe_upgrade_lock.13009.0QjKdM
-rw------- 1 root 87 Dec 19 2011 init.HX5yFo
-rw------- 1 root 87 Dec 19 2011 init.n2hBHn
-rw------- 1 root 48 Dec 19 2011
dkms_rpm_safe_upgrade_lock.5500.FxD1fL
-rw------- 1 root 16346 Mar 6 16:04 076f94f61d77d
drwx------ 2 joe 4096 May 26 08:17 acroread_500_500
-rw------- 1 root 16346 May 30 16:08 05e004fcfefe6
drwx------ 2 joe 4096 Jun 5 17:35 gpg-rhKeMO
drwx------ 2 joe 4096 Jun 20 11:38 gpg-4qjsVm
-rw------- 1 root 56 Jun 29 16:43
dkms_rpm_safe_upgrade_lock.22022.eJT06b
-rw------- 1 root 58 Jun 29 16:44
dkms_rpm_safe_upgrade_lock.22022.hLYGR9
-rw------- 1 root 48 Jun 29 16:45
dkms_rpm_safe_upgrade_lock.22022.S6fvcw
-rw------- 1 root 61 Jun 29 16:47
dkms_rpm_safe_upgrade_lock.22022.cywVtp
drwx------ 2 root 4096 Jul 3 14:05 kdecache-root
-rw------- 1 root 119826 Jul 10 08:15 066f25009bd33
-rw------- 1 root 25382 Jul 10 08:16 066f25005ef46
-rw------- 1 apache 44216320 Aug 1 04:02 core.4622
-rw------- 1 apache 44216320 Aug 1 04:02 core.4621
-rw------- 1 apache 44216320 Aug 1 04:02 core.4620
-rw------- 1 apache 44216320 Aug 1 04:02 core.4625
-rw------- 1 apache 44216320 Aug 1 04:02 core.4624
-rw------- 1 apache 44216320 Aug 1 04:02 core.4623
-rw------- 1 apache 44216320 Aug 1 04:02 core.4626
-rw------- 1 apache 44216320 Aug 1 04:02 core.4619
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