Just be careful which 64-bit version you grab. Some distros (like Debian) only have official support for the IA64 architecture (Intel Itanium), and the x86_64 architecture (AMD Athlon 64 and Opteron) is a separate, incompatible, architecture. There have been a couple of distributions based off of other projects that failed to understand this, and are distributing an IA64 build as an x86_64 build, and it crashes, badly, when you try to run it on AMD hardware.
There are a few distros that support both IA64 and x86_64, in that case, just make sure you grab the right one, since both are labeled as 64-bit builds.

George Joseph Thekkekara wrote:

All popular flavors like Fedora, Gentoo, Mandrake, RedHat, SuSE all
have precompiled version of their OS for AMD64. Try one of them.

Regards

George Joseph
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